City of Hope, Duarte, California
Over ten years of advanced research and development, American Gene Technologies™ (AGT), has built a broad, robust gene delivery platform that accelerates the development of a wide variety of drug candidates. This platform allows AGT to pursue exciting clinical “cures” in large and orphan indications to complex diseases. AGT has an extensive and growing patent portfolio protecting its lentiviral vector and proprietary process for generating autologous cell products that treat HIV as well as its methods and Composition for the Activation of Gamma Delta T cells to kill solid cancer tumors.
Using its platform and patented methods, AGT has built a rich product pipeline of genetic therapies for patients suffering from infectious disease, monogenic disorders, and cancer.
Its three lead programs for HIV, Immuno-oncology, and Phenylketonuria (PKU) are well into the laboratory phase and scheduled to move into the clinic. The Company is expecting to begin clinical trials this year for an HIV cure based on a successful pre-IND meetings with the FDA.
HIV CURE PROGRAM
- Granted 3 USPTO patents to protect its lentiviral vector and proprietary process for generating autologous cell products for treating HIV (“HIV Pre-Immunization and Therapy”)
- Signed Research Agreement with NIAID for Experimental HIV/AIDS Cure Strategy
- Former scientific advisor, Robert R. Redfield, M.D., was appointed Director of the Centers for Disease Control and Prevention (CDC)
- Completed process development for the AGT103-T automated cell manufacturing protocol; the GMP vector for the HIV cure program was completed.
- Selected University of Maryland, Baltimore (UMB) as the new clinical site for its non-IND study, AGT-CS168, to collect sample venous blood specimens from HIV positive individuals
USPTO Patents & FDA Designation
AGT’s patent portfolio protects its technology platform and methods. In addition to below, AGT has several patents pending and over 20 patent families represented by filings with the USPTO and international patent offices. Also, AGT has been granted FDA Orphan Drug Designation for its treatment of Phenylketonuria (PKU).