Rapid Drug

Development Platform

Advanced Gene & Cell

Therapy Platform

Yielding Cures for Serious Diseases

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HIV Cure Program

HIV+ Individuals Become Immune to HIV

No More Daily Antiretrovirals

Clinical Trial Forecast 2nd Half 2020

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Cancer Cure Program

Stimulating the Natural Immune System

(Gamma Delta T Cells) to Safely Remove

Solid Tumors

Human Trial Forecast for 2023

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Phenylketonuria

Cure Program

A One Time Treatment For PKU

That Lasts a Lifetime

Forecast for Human Trials 2022

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Rapid Drug Development Platform

Advanced Gene & Cell Therapy Platform
Yielding Cures for Serious Diseases

VIEW PIPELINE

HIV Cure Program

HIV+ Individuals Become Immune to HIV. No More Daily Antiretrovirals
Clinical Trial Forecast 2nd Half 2020

LEARN MORE

Cancer Cure Program

Stimulating the Natural Immune System (Gamma Delta T Cells)
to Safely Remove Solid Tumors
Human Trial Forecast for 2023

LEARN MORE

Phenylketonuria Cure Program

A One Time Treatment For PKU That Lasts a Lifetime
Forecast for Human Trials 2022

LEARN MORE
agt-starts-human-trials-hiv-2020

FDA APPROVES AMERICAN GENE TECHNOLOGIES (AGT) TO MOVE FORWARD WITH PHASE 1 CLINICAL TRIAL OF HIV CURE PROGRAM

Our Vision for an HIV Cure Attempt

HIV Cure Project Initiated: October 2016. AGT meets with the FDA and defines a path forward for AGT103-T. FDA outlines safety requirements and greenlights further development.

IND Submission: October 2019. The Investigational New Drug (IND) application provides preclinical data and a rationale for why this unique immuno-regulatory approach is worthy of advancing into the clinic.

IND Approved - Clinical Trials Begin: August 2020, FDA approves the IND and clears AGT to begin a Phase 1 human trial.

First Patient Enrolled - October 2020. AGT begins the Phase 1 trial for AGT103-T, and the first trial participant is expected to be infused early in 2021.

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Watch clips from AGT's red carpet event celebrating its IND submission to the FDA.

Who We Are Replacement Photo

Who We Are

American Gene Technologies International Inc. (AGT) is a private biotechnology company pursuing cures and treatments for infectious diseases, cancers and monogenic disorders.
AGT's programs are designed to:

Create immunotherapy for HIV disease with gene modified T cells
Activate innate T cell immunity capable of killing all tumor cells with its vector used in immuno-oncology
Treat PKU by bringing a functional gene into cells that express a dysfunctional gene due to mutation
Advance clinically to provide human proof of concept

What We Do

For over a decade, AGT has developed, tested and banked thousands of lentiviral vectors that can be adapted to the specific needs of new target diseases. AGT has developed gene therapy for diseases using this rapid gene delivery platform.

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Gene Therapies

AGT’s platform allows it to pursue clinical “cures” for complex diseases. The company has developed patent-protected gene therapeutics that are breakthroughs in medicine.

GENE THERAPY

HIV/AIDS

Immunotherapy for HIV disease with gene modified T cells

IMMUNO-ONCOLOGY

Activates innate T cell immunity capable of killing all tumor cells with its vector used in immuno-oncology

GENE THERAPY

Phenylketonuria (PKU)

Treats PKU by bringing a functional gene into cells that express a dysfunctional gene due to mutation

Pipeline

American Gene Technologies™ (AGT) is building a rich product pipeline based on its lentiviral vector platform. Our three lead programs are well into the laboratory phase and scheduled to move into the clinic over the coming months.

Our Executive Team

American Gene Technologies™ (AGT) is building a rich product pipeline based on its lentiviral vector platform. Our three leading therapeutics are well into the laboratory phase and scheduled to move into the clinical phase over the course of the next 6-18 months. AGT is in the process of testing and commercializing genetic medicines that will cure or halt the progression of several major diseases.

Jeff Galvin CEO of American Gene

Jeff Galvin

CEO and
Founder

Jeff earned his BA degree in Economics from Harvard in 1981. He has more than 30 years of business and entrepreneurial experience including founder or executive positions at a variety of Silicon Valley startups. Several of his companies were taken public and/or sold to public companies.

Dr. David Pauza

C. David Pauza, PhD

Chief Science
Officer

David has 35 years of experience in HIV, immunology, virology, and cancer biology, and has held faculty positions and at University of Wisconsin and University of Maryland medical schools. Prior to joining AGT, David was Adjunct Professor of Medicine at the University of Maryland Medical School in Baltimore.

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C. Neil Lyons, CPA

Chief Financial Officer &
Executive Vice President

Neil has more than 30 years of experience in finance, strategy, raising capital, SEC compliance, and corporate governance in both public and private companies, with over 10 years of that leading finance for publicly-traded, clinical-stage biotechnology companies.

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Kelly Huang, PhD

Director, Preclinical
Product Development

Kelly brings more than 10 years of experience in biopharma drug development, and has lead teams to support the development of drugs targeting diverse therapeutic areas including infectious disease, autoimmunity, and oncology.

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AGT's Core Objectives

Leverage our lentivirus platform to create highly-effective targeted genetic medicines
Create solutions for patients across a spectrum of infectious diseases, cancers and inherited disorders
Collaborate with leading medical researchers from around the globe
Partner with pharmaceutical and biotech firms on indication and platform-specific opportunities
Enhance our proprietary platform to expedite drug development

Is the cure for cancer right around the corner?…

Advances in gene technologies and the resulting cures are accelerating exponentially while costs are coming down. If you were in Silicon Valley for the last 35 years, you’d recognize parallels to many previous high-tech “explosions” such as microcomputers, software and the Internet. “Moore’s Law” now applies to drug development and the next big startup could be up in a garage near you! Forget zeroes and ones… A-C-G-T is the new growth area of programming and real-world solutions. Viva la revolution!

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