Dr. Conant, one of the first HIV/AIDS treatment pioneers, strengthens AGT’s capacity to progress toward a functional cure
American Gene Technologies (AGT) announces the appointment of Dr. Marcus A. Conant, a leading dermatologist in the U.S. and one of the first physicians to diagnose and treat AIDS, as special advisor to AGT CEO Jeff Galvin.
“I’m elated and honored to have Marcus on board as an advisor,” said AGT CEO Jeff Galvin. “He has been through the war, seen patients’ suffering firsthand, and yet he has maintained his optimism, his passion, and his empathy for everyone infected with and affected by HIV. Marcus agreed to work with AGT because he sees our treatment as the next step toward finding a cure for this horrific disease.”
Dr. Conant was the first physician to diagnose HIV in San Francisco while running the inpatient dermatology service at the University of California San Francisco. Before anyone recognized the virus or understood that it was about to become a global epidemic, Dr. Conant took the lead in forming the Kaposi’s Sarcoma Research & Education Foundation in 1982, which later became the San Francisco AIDS Foundation.
Dr. Conant conducted early clinical trials, persevering despite seeing 94% of patients die during the epidemic’s first years. His clinical experience sensitized him to the suffering caused by the disease. As a physician with a holistic perspective, Dr. Conant’s work expanded beyond the strictly clinical, to include education, research, and advocacy.
“After working with HIV/AIDS patients for 40 years, I am cautiously optimistic that a major turning point is near after looking at AGT’s data and process,” said Dr. Conant. “AGT’s work makes me hopeful we may have crossed the threshold and could at long last be seeing something that will work as a cure for people who have endured pain and suffering for years.”
Dr. Conant’s decades of on-the-ground medical experience in treating HIV/AIDS will be instrumental as AGT conducts the ongoing phase 1 trial of AGT103-T, a cell and gene therapy for HIV disease. His input will help AGT continue to make progress toward realizing a historic breakthrough to end the epidemic.
Phase 1 in the Maryland/D.C. Area
AGT’s Phase 1 trial for AGT103-T is currently underway at trial sites in the Maryland / Washington, DC area. The recruitment status of the phase 1 RePAIR (Restore Potent Antiviral Immune Responses) clinical trial along with information of the trial sites can be found on ClinicalTrials.gov. The trial is the company’s first step in clinical testing of cell and gene therapies for HIV, cancer, and rare diseases.
According to UNAIDS, approximately 37.7 million people worldwide live with HIV/AIDS. In the United States, government statistics show 1.2 million people have HIV and estimate that 34,800 Americans were newly infected with HIV in 2019. Across the globe, UNAIDS estimates that approximately 1.5 million individuals were newly infected with HIV in 2020. The Washington D.C./Baltimore area is often cited as a ‘hot spot’ for HIV, with Washington, D.C., having the highest rate of infection at nearly 46 cases per 100,000 population and Baltimore City having rates of 17 cases per 100,000. Maryland also ranks sixth among U.S. states and territories in HIV diagnosis rates, with more than 900 new cases in 2019 alone, according to the Maryland Department of Health.
Since the late 1980s, antiretroviral drugs have restored quality of life to persons living with HIV and, in some cases, have even been used to prevent new infections. However, no approved treatment has demonstrated the ability to cure HIV. AGT is committed to addressing this unmet medical need.
AGT103-T is a genetically modified cell product made from a person's own cells. AGT's unique approach focuses on repairing the key immune system damage caused by HIV. AGT’s goal is to develop a cell and gene therapy capable of repairing the immune system so it will provide natural control over HIV replication.
About American Gene Technologies
AGT is a gene and cell therapy company with a proprietary gene-delivery platform for rapid development of cell and gene therapies to cure infectious diseases, cancers, and inherited disorders. AGT's mission is to transform people's lives through genetic medicines that rid the body of disease. AGT has been granted four patents for the technology used to make AGT103-T and 11 patents for its unique immuno-oncology approach to stimulate gamma-delta (γδ) T cells to destroy a variety of solid tumors. The company has developed a synthetic gene for treating Phenylketonuria (PKU), a debilitating inherited disease. AGT's treatment for PKU has been granted Orphan Drug Designation by the Food and Drug Administration (FDA), and it is expected to reach the clinic in 2022.
American Gene Technologies
Phone: (410) 963-2345