Claims Scope:

Allowed.  Issue fee paid.  Awaiting patent certificate. 

Sequence (and Gene) Agnostic Method Claims 

Two sequence-specific guides  

Two sequence-specific guide+backbone (corrected) 

• Sequence agnostic method claim to CCR5 only, with a viral particle encoding a small RNA capable of inhibiting expression of CCR5  
• Sequence agnostic method claim to HIV gene, with a viral particle encoding a small RNA capable of inhibiting expression of at least one HIV gene  
• Two sequences with 80% identity to SIN 2, & 108 (mir21Vif, and corrected sequence mir185 Tat, any order) guide + backbone 
• Two of three sequences with 80% identity to SIN 1, 2 and 108 (mir30 CCR5, mir21Vif, and corrected mir185Tat) 
• Two of three sequences with 80% identity to SIN 97, 6 & & 7 (CCR5, Vif, and Tat, any order) guide only 
• Compositions & methods (broadest method claims agnostic to pre-immunized state; dependent claims include pre-immunization)