Claims Scope:

Allowed.  Issue fee due March 11, 2024. 

 

Sequence Specific Composition/System Claims:  

 

Non-integrating viral delivery system comprising (a) a viral carrier with a defective integrase gene;  

(b) a heterologous viral episomal origin of DNA replication;  

(c) a first sequence having at least one initiator protein specific for the heterologous viral episomal origin of DNA replication, the first sequence is inducible;  

(d) a second sequence encoding a gene product of interest (shRNA, siRNA, miRNA, etc.); 

(e) the viral origin of replication 95% identical to SEQ ID NO. 1.