Safe Lentiviral Vectors for Targeted Delivery of Multiple Therapeutic Molecules

Country:
US

Docket No:
436313-002436

Publication Number:
11,007,209

Patent Expiry:
10/19/2029

Claims Scope:

Patent issued May 18, 2021. 

 Method claims to a self-inactivating transfer vector free of wPRE;  

multiple gene units each operably linked to a regulatory sequence;  

a mammalian insulator sequence; and  

a helper construct lacking a 5’ LTR and replaced with a heterologous promoter, further having a non-functional envelope protein and a non-functional packaging sequence.