Claims Scope:

Patent issued August 11, 2020. 

Compositions and Methods (FDPS + CD47) (FDPS+ cMyc)* 

*Bold indicates sequence agnostic independent claim; underline indicates sequence specific independent claim 

Composition of viral vectors or particles containing first small RNA sequence complementary FDPS mRNA and second sequence complementary to CD47 or cMyc mRNA.  Dependent claim to a composition includes a third additional small RNA complementary to CD47 or cMyc. Method of treating or preventing cancer using compositions in combination with amino-bisphosphonate drugs.